Depending on the field of application, the algorithms considered differ in particular on the metrics used to qualify the groups of interest. There are a large number of methods for finding these subgroups that have been developed in different areas of research. Searching for subgroups of items with properties that differentiate them from others is a very general task in data analysis. The results demonstrate its ability to identify and support a short list of highly credible and diverse data-driven subgroups for both prognostic and predictive tasks. We compared Q-Finder with state-of-the-art approaches from both Subgroup Identification and Knowledge Discovery in Databases literature. To illustrate this algorithm, we applied it on the database of the International Diabetes Management Practice Study (IDMPS) to better understand the drivers of improved glycemic control and rate of episodes of hypoglycemia in type 2 diabetics patients. Those subgroups are tested on independent data to assess their consistency across databases, while preserving statistical power by limiting the number of tests. The top-k credible subgroups are then selected, while accounting for subgroups’ diversity and, possibly, clinical relevance. This allows Q-Finder to directly target and assess subgroups on recommended credibility criteria. It combines an exhaustive search with a cascade of filters based on metrics assessing key credibility criteria, including relative risk reduction assessment, adjustment on confounding factors, individual feature’s contribution to the subgroup’s effect, interaction tests for assessing between-subgroup treatment effect interactions and tests adjustment (multiple testing). In this paper, we present the Q-Finder algorithm that aims to generate statistically credible subgroups to answer clinical questions, such as finding drivers of natural disease progression or treatment response. However, both the limited consideration by standard SD algorithms of recommended criteria to define credible subgroups and the lack of statistical power of the findings after correcting for multiple testing hinder the generation of hypothesis and their acceptance by healthcare authorities and practitioners. Within the latter area, subgroup discovery (SD) data mining approach is widely used-particularly in precision medicine-to evaluate treatment effect across different groups of patients from various data sources (be it from clinical trials or real-world data). In randomized clinical trials (RCTs), confirmatory subgroup analyses focus on the assessment of drugs in predefined subgroups, while exploratory ones allow a posteriori the identification of subsets of patients who respond differently. Cannot detect your public IP Access to myQNAPcloud myQNAPcloud Link services.Addressing the heterogeneity of both the outcome of a disease and the treatment response to an intervention is a mandatory pathway for regulatory approval of medicines. Failed to access myQNAPcloud myQNAPcloud Link service. Accessed myQNAPcloud myQNAPcloud Link services. The user is not in the whitelist of the device. This device has been in your favorite device You have reached the maximum number of members. No mapped ports found! This device is not in your favorite list. The specified access code is not found for the device. The specified user is not found for the device. The device has not published any service.
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This is an abomination of a hack, and it made me cackle a lot. I created a new dedicated GitHub repository, simonw/til-db, and updated my action to store the binary file in that repo-using a force push so the repo doesn’t need to maintain unnecessary version history of the binary asset. The best place to put this would be an S3 bucket, but I find the process of setting up IAM permissions for access to a new bucket so infuriating that I couldn’t bring myself to do it. I needed a reliable way to store that 5MB (and probably eventually 10-50MB) database file in between runs of my action. The addition of the binary screenshots drove the size of the SQLite database over 5MB, so the part of my script that retrieved the previous database no longer worked. the site is hosted on Vercel, and Vercel has a 5MB response size limit.Įvery time my GitHub build script runs it downloads the previous SQLite database file, so it can avoid regenerating screenshots and HTML for pages that haven’t changed. # Now use puppeteer screenshot to generate a PNG proc2 = subprocess. # Use datasette to generate HTML proc = subprocess. til/til/python_debug-click-with-pdb.md page_html = str( TMP_PATH / "generate-screenshots-page.html") My generate_screenshots.py script handles this, by first shelling out to datasette -get to render the HTML for the page, then running puppeteer to generate the screenshot. So I reworked it to generate the screenshots inside the GitHub Action as part of the build script, using puppeteer-cli. but when a new article is added it’s not live when the build process works, so the generated screenshot is of the 404 page. I ran into a showstopper bug when I realized that the screenshot process relies on the page being live on the site. They’re pretty small-on the order of 60KB each-so I decided to store them in my SQLite database itself and use my datasette-media plugin (see Fun with binary data and SQLite) to serve them up. I needed to store the generated screenshots somewhere. It’s pretty resource intensive, so I also added a secret ?key= mechanism so only my own automation code could call my instance running on Vercel. Since the example was MIT licensed I created my own fork at simonw/puppeteer-screenshot and updated it to work with the latest Chrome. The example isn’t there any more, but I found the original pull request that introduced it. I remembered seeing an example of how to do this in the Vercel documentation a few years ago. My first attempt was to run Puppeteer in an AWS Lambda function on Vercel. The best way I know of programatically generating screenshots is to use Puppeteer, a Node.js library for automating a headless instance of the Chrome browser that is maintained by the Chrome DevTools team. So I decided to generate screenshots of the pages and use those as the 2x1 social media card images. One catch: my TILs aren’t very image heavy. I wanted them for articles on my TIL website since I often share those via Twitter. I really like social media cards- og:image HTML meta attributes for Facebook and twitter:image for Twitter. We’re now running that command as part of the Rocky Beaches build script, and committing the latest version of the YAML file back to the GitHub repo (thus gaining a full change history for that data). Sadly the Airtable API doesn’t yet provide a mechanism to list all of the tables in a database (a long-running feature request) so you have to list the tables yourself. This will create a folder called out/ with a. You run it like this: airtable-export out/ mybaseid table1 table2 -key=key So I built airtable-export, a command-line script for sucking down all of the data from an Airtable instance and writing it to disk as YAML or JSON. Natalie wanted to use Airtable to maintain the structured data for the site, rather than hand-editing a YAML file. Rocky Beaches is powered by Datasette, using a GitHub Actions workflow that builds the site’s underlying SQLite database using API calls and YAML data stored in the GitHub repository. It’s a new website built by Natalie Downe that showcases great places to go rockpooling (tidepooling in American English), mixing in tide data from NOAA and species sighting data from iNaturalist. I wrote about Rocky Beaches in my weeknotes two weeks ago. This week I figured out how to populate Datasette from Airtable, wrote code to generate social media preview card page screenshots using Puppeteer, and made a big breakthrough with my Dogsheep project. Weeknotes: airtable-export, generating screenshots in GitHub Actions, Dogsheep! Perhaps you have always had to dedicate an entire weekend or two every year when the time comes to spring clean again. With the house having had a thorough deep clean, you can come home and feel relaxed without having to worry about any cleaning that still needs to be done. We firmly believe that a beautiful clean home will improve your mood significantly when you get home from work. Getting professionals to spring clean your house will bring back the shine and sparkle to your home with minimal effort. After all not everyone would have the time to scrub the floors and wash the windows every week. We will however take before and after photos of some items to prove to the Managing Agent that without specialist intervention this is the best condition the item can be in.After a couple months, even a house that has been cleaned regularly may start to look a little too lived in. For instanceīondCleaninginNewCastle use the latest cleaning techniques and products however at times ‘normal wear and tear’ applies and itis not possible for us to get the item back looking like new. NOTE,each item will appear on the quote as a sperate service. Our quoting process covers these items individually, please make sure you have checked your quote for your inclusions. Carpet Shampoo Cleaning (Stain Removal Not included)įor Steam Clean please speciafically ask.Īnd if required any specialty service like.Bond Clean (Deep clean of the property).For instance, a complete Bond Clean usually consists of It is your duty to ensure you have covered them all. Please understand that Bond Cleaning can consist of many different components. Please see BondCleaninginNewCastle full Terms and Conditions. Our Bond ReturnGuarantee only covers the areas you have chosen to use our services (T's & C's Apply) . Our Bond cleaning service aims to clean the property to satisfy the Managing Agent (under the governance of the Residential Tenancies and Rooming Act 2008) of the cleanliness of that property for the tenant to have their bond released. Inclusions & Exclusions - BondCleaninginNewCastle You can contact our customer care representative to know more about our Spring Cleaning in Newcastle. Once we are done with our job, we request our customers to inspect the house thorough because there is no re-cleans on our spring cleaning service. We clean as per the list except your personal belongings, such as washing cutlery, crockery or making beds, etc. Our spring cleaners go to great lengths to ensure your beautiful home is spruced up from top to bottom without any mess according to your given list. Whether you require a one-off cleaning or want a quick clean before hosting a house party, we can provide you with a highly-professional and local-friendly cleaners who adhere to the highest quality of service. The service is designed to get rid of dust, dirt, harmful germs, and allergens from the house using chemical-free cleaning products. Our Expertise Leave the Hassles of Spring Cleaning to Usīond Cleaning Newcastle is a trusted cleaning company that specialises in thorough and reliable spring cleaning for your house in Newcastle, NSW. made explicit, help to define the interests and aims of their. There are anti-Semitic incidents every day, in the streets, in the trains. Identifying the rhetorical features of any manner of communication. This list is by no means comprehensive, but instead offers a primer to the language frequently used by scholars and students researching literary works. The Jews in Budapest are living in an atmosphere of fear and terror. Literary Terms Included below is a list of literary terms that can help you interpret, critique, and respond to a variety of different written works. Jews, listen to me! I can see a fire! There are huge flames! It is a furnace. "They'll never wake again! Never! Don't you understand?" It's so long since they closed theirĮyes. Ploce (pronounced PLO-chay) is a rhetorical term for the repetition of a word or name, often with a different sense, after the intervention of one or more other words. To this day, whenever I hear Beethoven played my eyes close and out of the dark rises the sad, pale face of my Polish friend, as he said farewell on his violin to an audience of dying men. The slogan 'I am stuck on Band-Aid, and Band-Aids stuck on me' is an example of ploce. "Man raises himself toward God by the questions he asks Him," he was fond of repeating. Monday passed like a small summer cloud, like a dream in the first daylight hours. He looked us over as if we were a pack of leprous dogs hanging onto our lives. Perhaps less than that even: a starved stomach. Suddenly, someone threw his arms around my neck in an embrace: Yechiel, brother of the rabbi of Sighet. The Jews of Sighet - that little town in Transylvania where I spent my childhood - were very fond of him. I had known that he was at the end, on the brink of death, and yet I had abandoned him.ĭuring the day I studied the Talmud, and at night I ran to the synagogue to weep over the destruction of the Temple. I would often sit with him in the evening after the service, listening to his stories and trying my hardest to understand his grief.ĭespite the trials and privations, his face still shone with his inner purity. What is Voice In literature, the voice expresses the narrator or author’s emotions, attitude, tone and point of view through artful, well thought out use of word choice and diction. Sprinkled sparsely, yet precisely through the straightforward narrative are language patterns that enhance thought and emotion. A professional journalist of Elie Wiesel's experience demonstrates that a knowledge and application of literary devices become a natural part of writing. No doubt, machines are replacing humans in terms of perfection, accuracy, efficiency and time saving. In addition to that, our shop offers power tools on finance, so you can get all benefits now and pay later. You’ll notice the drastic drop in your input costs when you engage mechanised labour instead of human labour. 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Having the mic audio jack plugged in even if the mic on the headset is tilted up, thus muting it, still makes a static noise for other people when the input sensitivity is low, so it isn't just my mic picking up the audio straight out of the speakers of my headset. This only happens when my headset is plugged in, so something about it is definitely the cause. I simply could not understand that as in my opinion these have close to zero perceived bass. Price: 139 (worldwide shipping available for 15) So about this Epos version of the. So I concluded that something was very off with the Game Zero's sound signature and watching Zeos review he said that these where V-Shaped. Connectivity: 3.5mm jack (2.5m 2 x 3.5 mm cable, 1.5m 1 x 3.5 mm cable) Weight: 253g. The only problem is that if I play music too loud or a loud noise occurs in a game, everyone else I talk to in Discord can hear it too except it is in really bad quality for them (they could hear everything, not only the loud noises, if I didn't have the input sensitivity at -45dB in Discord). Sennheiser Game Zero Sound Signature Solved. I've had this set of headphones for a few years, and since I've got them I have used them to play games, listen to music, and talk to friends. The slang way is to describe the how the meta is affecting the game itself, an example being “the metagame is so sorcerer favoured, I can’t play my pirates”. Another term, “metagame” is used in two different ways. One player is basically saying that the other player can only win because they’re “abusing” the best strategy. “Meta abuser” is similar to this term, but is used as a form of an insult or trash talk. “Meta slave” is a popular term that typically refers to a player who will only follow the meta, resulting in them playing the exact same thing the exact same way. The terminology meta has brought about a whole range of slang to gaming culture. This team specifically looks at what effect a buff/nerf to an entity will have on the game as a whole. Companies and teams that are big enough to hire one, will often implement a balance team. This continuously challenges developers in ensuring that all aspects of the game are kept balanced. In other words, if the entity is not directly changed, but somehow becomes stronger, it means that the entity has experienced “power creep”. When something in a video game becomes meta/strong due to changes around it, this is known as “power creep”. For example, if Riot decides to buff an item that can be built in League of Legends, they need to factor in:Ī) What this item actually does and how much it needs a buff.ī) What champions build this item and how strong are they?Ĭ) How this may affect champions that are countered by said item?ĭ) Will this item change the pacing of the game or disrupt the typical understanding of the game for players? This means that developers need to take into account everything when looking to change a game. In Rainbow Six there is always a more favourable option considered by the community.Ī meta works in-depth with all aspects of an online game. Rainbow Six Siege has had many aspects of its gameplay thought of as meta, from which characters you choose, to which gun you pick on them, even to which map/side you play. Even in highly tactical first-person shooters metas still exist. These cards can synergise together so well in a deck that it makes the deck much more powerful than other options - which makes it “meta”. Hearthstone allows players to build specific decks out of 30 cards. Another example can be included in Hearthstone, Blizzard Entertainment’s fantasy card game. As the game grew, changed and flowed, so too did the meta. League has been known to have a meta since its inauguration. Take League of Legends, one of the world’s most popular online competitive games. They guide and shape the way games are played.Įxample of metas can be found almost everywhere, in all forms of competitive gaming. Metas can include anything, from picking a specific character, to playing in a certain way. Metas have shaped the way we look at traditional and contemporary online gaming and have had an insanely large impact on the industry, particularly in esports. Some people have defined meta as an acronym meaning “most effective tactics available”. Said strategy is considered to be the most optimal way to win/ has the best performance at a specific task. In essence, a "meta" in gaming terminology is a generally agreed upon strategy by the community. He was one of the coaches of the singing reality show ‘The Voice of Nepal’. Timilai Dekhera Himal Haseko, Badal Pariko Desh Baat, Sayad Timro Baatoma, Parkhaima are some his popular songs. Bisalchautari Tv 564K subscribers Share 25K views 11 months ago RajuLama bisalchautaritv DiyaPun Raju Lama And Diya Pun Interview Mount Everest Climbing. Lama is also the lead vocalist of popular music band Mongolian Heart and has been active in environmental campaigns lately. They also gave a concert at Camp 3 at an altitude of 6,574 meters. 2022 May 05, 6:52, Famous singer Raju Lama has given a performance at a height of 6574 meters. Lama said he climbed the highest peak to convey the message of the effects of climate change. Singer Raju Lama has performed a solo concert at an altitude of 6,574 metres, aiming to aware the world of the effects of global warming and climate change. Everest the worlds’ highest snow peak standing at the height of 8848.86 meters has been topped by many Nepalese and foreign alpinists since first successfully climbed 1953 by Sir Edmund Hillary and Tenjing Norgay Sherpa. Some of his highly notable songs are Parkhaima. The team consisted of climbers from Nepal, China, Australia, Russia and Pakistan. Raju Lama is back On Air Raju Lama is a singer-songwriter, vocalist of Mongolian Heart, photography and travel enthusiast, and an Everester. Mingma Ji, who led the expedition, climbed Mt. Everest on behalf of Imagine Nepal Expedition. Congratulations to all,” read a post on the Facebook page of Imagine Nepal Everest Expedition.Īlong with singer Lama, 27 people climbed Mt. Everest 8848.86 today () morning in between 4 am and 6:40 am. “Our Imagine Nepal Everest Expedition 2022 Team summited Mt. He said that he is very happy to be able to give a concert at an altitude of 7900 meters. Everest, but also to find a way of change by showing the impact of climate change on the society. Raju Lama said that his goal is not only to climb Mt. He reached atop the highest peak at 6:40 am on Monday together with 26 other climbers of his expedition team.Īccording to Imagine Nepal Expedition, singer Lama has conquered the 8848.86-meter high peak. Raju Lama KATHMANDU, MAY 16 Singer Raju Lama, who had previously performed a solo concert at an altitude of 6,574 metres, successfully scaled Mt Everest this morning. Singer Raju Lama is overjoyed after successfully climbing Mt. He had ascended the highest peak this year through Imagine Nepal Expedition to spread the message against climate change. Popular singer Raju Lama has successfully climbed Sagarmatha (Mount Everest), the highest peak of the world. KATHMANDU, Raju Lama, the famous Nepali songwriter and singer of musical band Mongolian Heart was welcomed at the Tribhuvan International Airport today with the national flag and musical instruments. This agrees with our previous observations on powder, single crystal, and film samples of (Li, Fe)OHFeSe superconductors. The microstructure evolution and mechanical properties of Mg6Zn0.5CexMn (x 0 and 1 wt.) wrought magnesium alloys were researched, and the morphologies and role of Mn element in the experimental alloys were analyzed. The observed positive correlation between the T c and lattice parameter c, regardless of the Mn doping level z, indicates that a larger interlayer separation, or a weaker interlayer coupling, is essential for the high- T c superconductivity in (Li, Fe)OHFeSe. It is an organizing icon of chemistry and is widely used in physics and other sciences. We propose that, with increasing doping level, the Mn dopant first occupies the tetrahedral sites in the (Li, Fe)OH layers before starting to substitute the Fe element in the superconducting FeSe layers, which accounts for the V-shaped change in cell parameter c. e The periodic table, also known as the periodic table of the elements, arranges the chemical elements into rows ('periods') and columns ('groups'). Interestingly, we find that the superconducting transition temperature T c and unit cell parameter c of the Mn-doped (Li, Fe)OHFeSe samples display similar V-shaped evolutions with the increasing dopant concentration z. The distribution homogeneity of the Mn element incorporated into the lattice of (Li, Fe)OHFeSe is checked by combined measurements of high-angle-annular-dark-field (HAADF) imaging and electron energy-loss spectroscopy (EELS). Several prokaryotes can reduce Mn(IV) to Mn(II), and some organisms can derive sufficientĮnergy from manganese reduction to support growth (reviewed by Nealson AND Saffarini, 1994).We synthesize a series of Mn substituted (Li, Fe)OHFeSe superconductor single crystals via a modified ion-exchange method, with the Mn concentration z (the atomic ratio of Mn:Se) ranging from 0 to 0.07. Where the element is most commonly found in nature, and how it is sourced commercially. The role of the element in humans, animals and plants. The description of the element in its natural form. Bacteria import manganese via ABC transporters and P-type ATPases, and yeastĪre known to use NRAMP family metal transporters for manganese uptake (reviewed by Culotta, 2000). This is where the artist explains his interpretation of the element and the science behind the picture. The mechanisms and regulation of manganese transport in bacteria and yeast have beenĬharacterized. Were found to influence the carbohydrate degradation pathway used by Deinococcus radiodurans ( Zhang et al, 2000). Relative levels of manganese and iron in growth medium also have an absolute requirement for manganese butĭo not require iron for growth ( Imbert and Blondeau, 1998). The causative agent of Lyme disease, use manganese and iron is not required ( Posey and Gherardini, 2000). All of the metalloproteins in Borrelia burgdorferi, The elements P, As, and Bi are in the same family on the periodic table and the elements Co, Ni, and Hg are all transition elements are true. (reviewed by Jakubovics and Jenkinson, 2001). Manganese is known to be required for both endospore formation and germination in Bacillus spp. Since been found in other bacteria (reviewed by Que and Reynolds, 2000). Additional examples of these enzymes, which were previously known in only iron-containing forms, have The first known manganese-containing aromatic ring cleavage dioxygenase was discovered inīacillus brevis. Manganese is an essential component of the oxygen-evolving complex in photosystem II in plantsĪnd cyanobacteria ( Keren et al, 2002). Superoxide radicals and hydrogen peroxide (reviewed by Have been described and some bacteria also use low molecular weight Mn(II) complexes to scavenge Two manganese enzymes that protect bacterial cellsįrom active oxygen species, superoxide dismutase and pseudocatalase, In general, the relevant redox functions of manganese inĮnzymes come into play largely with oxygen as the substrate Several hydrolytic enzyme-catalyzed reactions (reviewed by Crowley et al, 2000). The research shows that all of Mn elements form the 1 Keywords Mg6Zn0. Manganese also acts as a superacid catalyst in open access Abstract The microstructure evolution and mechanical properties of Mg6Zn0.5Cex Mn ( x 0 and 1 wt.) wrought magnesium alloys were researched, and the morphologies and role of Mn element in the experimental alloys were analyzed. In this regard, manganese has been useful in substitutionsĪnd EPR spectroscopic probes of active site architecture andĬatalysis (reviewed by Reed and Poyner, 2000). Of enzymes and, in some cases, substrates such as Mn ATP. With this group in providing structural charge stabilization So it is not surprising that there is overlap in function Is largely restricted to Mn 2+ complexes.īoth Mn 2+ and Mn 3+ are found in enzymes. Than any other element, but the aqueous chemistry of manganese Manganese can exist in 11 oxidation states (+7 to -3), more Manganese has a multi-faceted role in biological systems. Now, listen-you definitely don’t need a dedicated retinol for under your eyes if you’re already using a retinol face serum (just smooth that serum around your eyes every day). It visibly diminished fine lines as well as illuminated my under-eye area.” “At the same time, it was not sticky at all. THE REVIEWS: “This eye cream is smooth and silky, and it absorbs amazingly well,” writes one tester. Key ingredients: Vitamin C, niacinamide, coQ10.I find that it's also really smoothing, thanks to added niacinamide and coQ10 (an antioxidant that can potentially help soften wrinkles). Vitamin C, the superstar ingredient in the formula, “ helps reduce the appearance of dark circles by fading hyperpigmentation,” says dermatologist Dendy Engleman, MD, “but because it’s an antioxidant, it also defends your skin from free-radical damage, which can contribute to the appearance of dark circles and premature aging,” Dr. It has a rich consistency that makes my under-eyes look radiant and smooth in the morning, yet also gives me lots of moisture at night. Cute packaging too!”īeauty editor perks: I tested Ciara’s skincare line, OAM, in advance of the launch last year, and this vitamin-C eye cream blew me away. It leaves your delicate skin feeling supple while minimizing fine lines due to the softening effect. THE REVIEWS: One reviewer writes, “This Retinoid balm formula is perfect around the eyes because it does not migrate. Key ingredients: Granactive retinoid, sunflower-seed oil and wax, jojoba esters, black-currant oil.I consider it the leveled-up version of under-eye slugging. This balm is majorly moisturizing, thanks to jojoba esters, sunflower-seed oil and wax, and black-currant oil, but it also uses granactive retinoid-a gentle-ish retinoid that helps smooth, firm, and brighten my skin over time. Enter: My personal favorite eye balm from Versed (if you see me in the comments suggesting this, yes you did <3). And while I think those occlusive ointments can be a great option to boost moisture, they won’t do too much else. My entire TikTok FYP is filled with people swearing by dabbing Vaseline or Aquaphor on their under-eyes before bed to prevent wrinkles and reduce puffiness and dark circles. Peep them all here: Our top picks for the best eye creams for dark circles of 2023: After testing more than 30 formulas on my dark, puffy under-eyes (yup, I have genetic under-eye bags too), I compiled this list of the 15 best eye creams for dark circles. Still, I wasn’t ready to throw in the towel yet, which is why I went on a hunt for the best eye creams for dark circles, per the advice of the experts.Īfter testing dozens of eye creams for dark circles, I found that the best formulas contain brightening, hydrating, and de-puffing ingredients-and that they’re def not all equal. Hartman, MD, and Dendy Engleman, MD), I learned that aging, allergies, tiredness, and genetics can play a major role in your under-eye darkness-which means there’s only so much you can do to help them at home. But after speaking to a few dermatologists (hi, Corey L. Like, no matter how much under-eye concealer, color corrector, or brightening setting powder I layered on, my under-eyes always make me look tired as hell, even when I go to bed at 8 p.m. I swear the day I entered my late 20s, I started having unruly dark circles. |
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